Montefalco, placed in a dominant position over the valleys of the Topino and the Clitunno rivers, offers a wide panorama of the Umbrian land. Influential painters and poets have stayed on this sunny hill, including Benozzi Gozzoli, the Florentine painter of the early Renaissance who illustrated St. Francis of Assisi's life through a cycle of frescoes now visible within the present Museum Complex of St. Francis and Herman Hesse who has walked through its narrow streets looking for a particular to stop in time.

An excellence of the territory that made famous Umbria around the world is the Sagrantino of Montefalco, the local red wine that reflects the scents and the true flavors of the area.